Is simvastatin still a good drug?

There was a report released recently about simvastatin being less effective than one of the more experienced statins at reducing certain measures of cardiovascular risk, despite its ability to lower the LDL cholesterol (the “bad” cholesterol) levels. 

My first word of caution regarding this: the study was performed in a very select group of individuals, people with a genetic disorder contributing to markedly elevated cholesterol levels that affects less than 1% of the population.  Right off the bat, you would be hard-pressed to apply the results of this study to the larger population (not sure why they even bothered).

It very well may not be as effective at reducing cardiac risk as we once thought, but until there is a more clear answer it shouldn’t be shunned quite yet.  As a generic drug, it is cheap and most often quite effective at lowering the LDL.  I expect there will be more detailed outcome studies comparing simvastatin with other statins. 


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